Detalhe da pesquisa
1.
The ketone body ß-hydroxybutyrate shifts microglial metabolism and suppresses amyloid-ß oligomer-induced inflammation in human microglia.
FASEB J
; 37(11): e23261, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37878335
2.
Regio-Specific N-Glycome and N-Glycoproteome Map of the Elderly Human Brain With and Without Alzheimer's Disease.
Mol Cell Proteomics
; 21(11): 100427, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36252735
3.
The role of FUT8-catalyzed core fucosylation in Alzheimer's amyloid-ß oligomer-induced activation of human microglia.
Glia
; 71(5): 1346-1359, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36692036
4.
Cholesterol, Amyloid Beta, Fructose, and LPS Influence ROS and ATP Concentrations and the Phagocytic Capacity of HMC3 Human Microglia Cell Line.
Int J Mol Sci
; 24(12)2023 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37373543
5.
Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia.
Glia
; 68(11): 2377-2394, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32525239
6.
Metabolic flux analysis of the neural cell glycocalyx reveals differential utilization of monosaccharides.
Glycobiology
; 30(11): 859-871, 2020 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32337579
7.
Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity.
FASEB J
; 32(5): 2866-2877, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29401580
8.
Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept.
Brain
; 141(2): 596-612, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29272333
9.
The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo.
Glia
; 66(9): 1881-1895, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30043400
10.
Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome.
Neurobiol Dis
; 109(Pt A): 25-32, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-28927958
11.
A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta.
Molecules
; 23(8)2018 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30103547
12.
Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia.
Glia
; 65(1): 106-121, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27696527
13.
CX3CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model.
Brain Behav Immun
; 60: 106-116, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26883520
14.
Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity.
J Neurosci
; 35(6): 2516-29, 2015 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25673846
15.
Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure.
Biochim Biophys Acta
; 1854(12): 1860-1870, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26374940
16.
Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3ß of substituted quinolines.
Bioorg Med Chem Lett
; 24(15): 3392-7, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24951331
17.
Effects of Sex and Western Diet on Spatial Lipidomic Profiles for the Hippocampus, Cortex, and Corpus Callosum in Mice Using MALDI MSI.
J Am Soc Mass Spectrom
; 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38456419
18.
Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes.
Commun Biol
; 7(1): 195, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38366025
19.
Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer's disease.
Sci Rep
; 13(1): 7816, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37188790
20.
Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity.
J Biol Chem
; 286(5): 3693-706, 2011 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20971854